A new study conducted by NeOnc into the efficacy of its NEO 100 formulation to safely deliver therapeutics to the brain through the Blood-Brain Barrier was concluded in August 2020. This study was done to specifically study not only the ability to permeate the BBB but also the impact such migration would have on the area of transfer. The maintenance of BBB integrity is essential for CNS homeostasis, so it is critical that any attempt to permeate the BBB be reversible and non-damaging to the tissue. This study showed that NEO100 transiently and reversibly permeabilizes the BBB at subcytotoxic doses thereby delivering to the brain with no damage to the BBB.

The study indicated that NEO100 opens the BBB in a reversible and nontoxic fashion in vitro and in vivo. It enabled increased brain entry of all tested therapeutics and was tolerated by animals. Mechanistic studies revealed the effects of NEO100 on different BBB transport pathways, along with the translocation of tight junction proteins from the membrane to the cytoplasm in brain endothelial cells.

Read The Paper

NEO100 enables brain delivery of blood-brain barrier impermeable therapeutics.

Authors: Weijun Wang¹, Nagore I. Marín-Ramos¹, Haiping He^1,2, Shan Zeng^1,2, Hee-Yeon Cho¹, Stephen D. Swenson¹, Long Zheng³, Alan L. Epstein³, Axel H. Schönthal4, Florence M. Hofman³, Ligang Chen² and Thomas C. Chen^1,4

¹Department of Neurological Surgery, USC, Luzhou, China, ²Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, China, ³Department of Pathology, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA, ⁴Departments of Microbiology and Immunology, Keck School of Medicine, USC, Los Angeles, California, USA.